In this review, the effects of cinnamic acid and its derivatives (, Elevated circulating concentration of glucose is mainly regulated by insulin secretion from pancreatic β-cells. Molecular mediators of hepatic steatosis and liver injury. A review of the efficacy and safety of oral antidiabetic drugs. ; Katiyar, C.; Kanaujia, A.; Duggar, R.; Singh, Y.; Srinivas, K.; et al. Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release. Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G. Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management. Targeting key metabolic and regulatory hepatic enzymes to enhance glycolysis and suppress gluconeogenesis serve as feasible approaches for treatment and management of diabetes [, Cinnamic acid derivatives are able to regulate the key enzymes of hepatic glucose homeostasis including glycolysis, glycogenesis (glucokinase and glycogen synthase), and gluconeogenesis (pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-bisphosphatase, and glucose-6-phosphatase), especially in diabetic states. Nielsen, L.; Khurana, R.; Coats, A.; Frokjaer, S.; Brange, J.; Vyas, S.; Uversky, V.N. Pérez-Jiménez, J.; Fezeu, L.; Touvier, M.; Arnault, N.; Manach, C.; Hercberg, S.; Galan, P.; Scalbert, A. Dietary intake of 337 polyphenols in French adults. Investigation of the kinetics of insulin amyloid fibrils formation. Raptis, S.A.; Dimitriadis, G.D. ; Ahn, Y.H. investigated anti-hyperglycemic potential of, Adiponectin is generally expressed in and secreted from adipose tissue, which plays a vital role in the modulation of glucose and lipid metabolisms in insulin-sensitive tissues such as liver and skeletal muscle [, Adipocytes are the main component of adipose tissues and are considered as the regulators of energy balance and glucose homeostasis [, Protein tyrosine phosphatase 1B (PTP1B) is the enzyme that catalyzes protein tyrosine dephosphorylation from insulin receptor and insulin receptor substrate. Clin. ; Ullah, M.O. ; El-Said, A.M.; Khalifa, S.A.; Göransson, U.; Bohlin, L.; Borg-Karlson, A.K. ; Xie, F.B. Cinnamic acid is a central intermediate in the biosynthesis of a myriad of natural products including lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and phenylpropanoids. Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells. The structure was confirmed by MS and 1H NMR. Bioavailability of hydroxycinnamates: A brief review of in vivo and in vitro studies. The inhibitory effect of cinnamic acid on AGE formation may be caused by its binding on HSA subdomain IIA (Sudlow’s site I) [, Glycation is not only an important cause of AGE-induced protein modification and alteration, but it also induces oxidation-dependent tissues and protein damage. Zhao, L.; Jiang, S.J. Nemet, I.; Varga-Defterdarović, L.; Turk, Z. Methylglyoxal in food and living organisms. Aceituno-Medina, M.; Mendoza, S.; Rodríguez, B.A. ; Adisakwattana, S. Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro. © 2017 by the authors. Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. Bhattacharya, S.; Oksbjerg, N.; Young, J.F. ; Buss, G.D.; Ishii-Iwamoto, E.L.; Salgueiro-Pagadigorria, C.; Comar, J.F. In skeletal muscle and adipose tissues, insulin-stimulated glucose uptake primarily occurs through several signaling pathways. Giacco, R.; Costabile, G.; Pepa, G.D.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R.; et al. ; Jannot, M.F. Adisakwattana, S.; Moonsan, P.; Yibchok-Anun, S. Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats. ; Jairajpuri, Z.S. ; Marin, D.; Puigpinos, A.; Mendieta, L.; Tarragó, T.; Morel, A.F. Chang, H.K. formally request permission using Copyright Clearance Center. The worldwide epidemiology of type 2 diabetes mellitus—Present and future perspectives. Li, W.; Zhao, X.; Sun, X.; Zu, Y.; Liu, Y.; Ge, Y. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage Ae. first series of cinnamic acid derivatives that inhibit GLIC currents at a micromolar range. However, due to the limited intestinal absorption being a result of low bioavailability of cinnamic acid and its derivatives, current improvement efforts with entrapping into solid and liquid particles are highlighted. The common cinnamic acid derivatives include p-coumaric acid, caffeic acid, and ferulic acid. Cinnamic acid derivatives are widely used in cosmetics and possess various functions. ; Yibchok-anun, S. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. Help us to further improve by taking part in this short 5 minute survey, Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes, S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation, http://creativecommons.org/licenses/by/4.0/, adenosine monophosphate-activated protein kinase, hepatic carnitine palmitoyltransferase 1a, peroxisome proliferator activated receptor alpha, peroxisome proliferator activated receptor gamma, sodium-dependent glucose co-transporter-1, Ferulic acid reduces plasma glucose and increases plasma insulin level in normal rats, Cinnamic acid enhances glucose-induced insulin secretion in the isolated mice islets, Cinnamic acid improves glucose tolerance in diabetic rats, Caffeic acid enhances glucose-induced insulin secretion in INS-1 pancreatic β-cells, Ferulic acid regenerates pancreatic islets in STZ-induced diabetic rats and reduces apoptosis and inflammation through a decline in level of IL-1β and TGF-β1, Ferulic acid increases islet number and sizes and reduced insulitis grades in diabetic rats when co-administration with metformin and thiazolidinedione, Cinnamic acid prevents palmitic acid-induced lipotoxicity in mouse NIT-1 pancreatic β-cells, Cinnamic acid inhibits palmitic acid-induced alteration of lipogenic gene and protein expression (AMPK, SREBP-1c, FAS, ACC), Hydrogen bonding and the formation of π-interaction are the main binding mode of caffeic acid with DPP-IV, Isoferulic acid activates α-1A adrenoceptor, thereby stimulating glucose uptake via PLC-PKC pathway in C, Combination of ferulic acid with metformin or thiazolidinedione demonstrates synergistic effect on glucose uptake in rat L6 myotubes, Ferulic acid prevents saturated fatty acid-induced defects in the insulin receptor through the blockage of PKCε activation and thereby permission of HMGA1 to activate insulin receptor β promoter in rat L6 myotubes, Ferulic acid and caffeic acid lower glucose production through suppression of gluconeogenesis and glycogenolysis by increasing the level of glucokinase mRNA in rat hepatoma Fao cells, Caffeic acid and cinnamic acid improve insulin resistance in tumor necrosis factor-α induced insulin resistant mouse liver FL83B cells by promoting insulin receptor tyrosyl phosphorylation and up-regulating the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2 (GLUT2), Caffeic acid lowers the blood glucose and glycosylated hemoglobin levels in diabetic mice strain C57BL/KsJ-db/db by an attenuation of hepatic glucose output, Isoferulic acid modulates mRNA expression of PEPCK and GLUT4 in STZ-induced diabetic rats by activating α-1A adrenoceptors to enhance the secretion of endogenous β-endorphin, Ferulic acid reduces hepatic glucose production by increasing glucokinase mRNA expression, Ferulic acid suppresses blood glucose in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen increased plasma insulin levels, Ferulic acid improves blood glucose, serum insulin and glucose tolerance in high-fat diet and fructose-induced type 2 diabetic rats by suppressing mRNA expression of PEPCK and glucose-6-phosphatase, Ferulic acid reduces the elevated blood glucose and lowers the insulin resistance in high-fat diet-induced obese mice by reducing expression of hepatic SREBP1c, FAS, and ACC concomitant with the up-regulating CPT1a and PPARα, Ferulic acid reduces hepatic fat deposition in oleic acid-stimulated HepG2 cells by the down-regulation of gene expression of FAS, ACCα, ACCβ, and SREBP-2, Caffeic acid and ferulic acid regulate adiponectin secretion through inhibition of NF-κB during inflammatory process, Cinnamic acid stimulates adiponectin secretion and increased the phosphorylation of AMPK in 3T3-L1 adipocytes through Gi/Go-protein-coupled receptor signaling pathway, Cinnamic acid inhibits PTP1B with a fast binding, Caffeic acid, ferulic acid, and isoferulic acid demonstrate a mixed-inhibition against intestinal maltase, Ferulic acid and isoferulic acid display mixed noncompetitive mode of inhibition towards intestinal sucrase, whereas caffeic acid is a non-competitive inhibition, Ferulic acid inhibits intestinal glucose uptake by interfering GLUT2, Cinnamic acid inhibits fructose-induced AGEs and fructosamine formation in bovine serum albumin, Cinnamic acid inhibits glucose-induced protein glycation in human serum albumin, Ferulic acid inhibits glucose-, fructose-, and ribose-induced AGEs and fructosamine formation in bovine serum albumin, Ferulic acid and isoferulic acid prevent glycation-induced oxidative damage to bovine serum albumin, Ferulic acid reduces high glucose-induced glycated hemoglobin, lipid peroxidation, and impairment of Na, Ferulic acid and isoferulic acid inhibit methylglyoxal-induced protein glycation and oxidative damage to protein and DNA, Ferulic acid prevents methylglyoxal-mediated cell apoptosis and oxidative stress in HepG2 cells, Ferulic acid prevents methylglyoxal-mediated cell apoptosis in pancreatic β-cells, Isoferulic acid prevents methylglyoxal-induced changes in structural and functional properties of human HDL, Caffeic acid inhibits glucose- and fructose-induced AGEs and fructosamine formation in bovine serum, Caffeic acid inhibits methylglyoxal-induced protein glycation in bovine serum albumin and histone, Ferulic acid inhibits the formation of insulin amyloid fibril. to access the full features of the site or access our. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. Adisakwattana, S.; Hsu, W.H. ; Bhattacharya, S.; Dasgupta, S. A polyphenol rescues lipid induced insulin resistance in skeletal muscle cells and adipocytes. Mechanism of the degradation of non-enzymatically glycated proteins under physiological conditions. Aune, D.; Keum, N.; Giovannucci, E.; Fadnes, L.T. El-Seedi, H.R. Rattanangkool, E.; Kittikhunnatham, P.; Damsud, T.; Wacharasindhu, S.; Phuwapraisirisan, P. Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant. ; Tsapas, A.; Wender, R.; Matthews, D.R. Authors contributing to RSC publications (journal articles, books or book chapters) A review on anti-inflammatory activity of phenylpropanoids found in essential oils. ; Vidal, J.; Cnop, M.; Kahn, S.E. Needless to say, it is possible according to the invention to use cinnamic acid or its derivatives alone or as a mixture. Inzucchi, S.E. MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. ; Lu, Z.Q. Cinnamic acid is an organic acid occurring naturally in plants that has low toxicity and a broad spectrum of biological activities. ; Koo, S.H. In the last 10 years, a lot of research and development of cinnamic acid derivatives as inhibitors of the α-glucosidase enzyme has been done. Ellagic acid and its conjugates form the majority of phenolic acids in red raspberries. Chen, L.; Magliano, D.J. ; Yoo, N.H.; Lee, Y.M. Sompong, W.; Meeprom, A.; Cheng, H.; Adisakwattana, S. A comparative study of ferulic acid on different monosaccharide-mediated protein glycation and oxidative damage in bovine serum albumin. ; Pinto, B.M. ; Jeppesen, P.B. Wang, S.S.; Liu, K.N. Acids, esters, amides, hydrazides and related derivatives of cinnamic … ; Naseemb, I.; Ahmad, I. Bian, X.; Fan, X.; Ke, C.; Luan, Y.; Zhao, G.; Zeng, A. Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-. ; Cheng, J.T. ; Orgaz, F.; Mansilla, F.; Montaño, A. Hafizur, R.M. ; Park, Y.B. Scheen, A.J. Hanhineva, K.; Törrönen, R.; Bondia-Pons, I.; Pekkinen, J.; Kolehmainen, M.; Mykkänen, H.; Poutanen, K. Impact of dietary polyphenols on carbohydrate metabolism. Adisakwattana, S.; Roengsamran, S.; Hsu, W.H. Traductions en contexte de "cinnamic acid" en anglais-français avec Reverso Context : the invention relates to substituted cinnamic acid nitriles of the formula contained in this article in third party publications American Diabetes Association. De Cássia da Silveira e Sá, R.; Andrade, L.N. The cinnamic acid derivative is an important part of the quinazoline derivative which exerts its activity. ; Hsu, F.L. ; Bracht, A.; Constantin, J. Metabolic effects of. ; Dong, H. Effects of berberine and cinnamic acid on palmitic acid-induced intracellular triglyceride accumulation in NIT-1 pancreatic β cells. Ma, Y.; Kosińska-Cagnazzo, A.; Kerr, W.L. Vague, P.; Coste, T.C. Anantharaju, P.G. Sulatskaia, A.I. Penkov, D.N. ; Subhan, N.; Hossain, H.; Hossain, M.; Reza, H.M.; Rahman, M.M. ; Chen, W.C.; Cheng, J.T. ; Nelson, R.G. Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in vitro. ; Sannigrahi, S.; Rahaman, N.; Ahmed, F. Treatment with ferulic acid to rats with streptozotocin-induced diabetes: Effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell. Kang, J.H. Hsu, C.L. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … The couples of compounds differed for the kind of aromatic substitution (p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, dihydroxy). ; Lai, T.Y. Adisakwattana, S.; Pongsuwan, J.; Wungcharoen, C.; Yibchok-anun, S. In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B. Insulin resistance and adipogenesis: Role of transcription and secreted factors. ; Hsu, F.L. Dasgupta, S.; Bhattacharya, S.; Maitra, S.; Pal, D.; Majumdar, S.S.; Datta, A.; Bhattacharya, S. Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. Several cinnamic acid derivatives have been reported to exhibit antiviral activity. In this study, we prepared 17 synthetic cinnamic acid derivatives and screened them to identify an effective antiviral compound against hepatitis C virus (HCV). Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds. Liu, I.M. The cinnamic acids [(2E)-3-phenylprop-2-enoic acid] and its four homologous derivatives such as p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, and dihydroxy are well known for their antioxidant, antitumor, antimicrobial, and antimycobacterial properties. Radtke, J.; Linseisen, J.; Wolfram, G. Phenolic acid intake of adults in a Bavarian subgroup of the national food composition survey. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. ; Jeon, S.M. Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Elosta, A.; Ghous, T.; Ahmed, N. Natural products as anti-glycation agents: Possible therapeutic potential for diabetic complications. Methylglyoxal, glyoxalases and the development of diabetic complications. It is worth mentioning that these polymers have a wide spectrum of applications, ranging from industrial (e.g. ; Hameed, A.; Shukrana, M.; Raza, S.A.; Chishti, S.; Kabir, N.; Siddiqui, R.A. Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro. Cinnamic acid and its derivatives occur naturally in high levels of plant-based foods. ; El-Refaei, M.F. Oxidative damage of DNA induced by methylglyoxal in vitro. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. Islet amyloid polypeptide and type 2 diabetes. In the category of phytochemicals that can be found in food, there are : α-Cyano-4-hydroxycinnamic acid Caffeic acid – burdock, hawthorn, artichoke, pear, basil, thyme, oregano, apple with the reproduced material. Han, H.S. Valentová, K.; Truong, N.T. Please enable JavaScript Stein, S.A.; Lamos, E.M.; Davis, S.N. ; Wei, X.; Qi, F.M. ; Giralt, E.; Dalcol, I.I. With recent insight into the development of dietary supplements and functional foods, search of effective phytochemical compounds and their mechanisms involved in prevention and management of diabetes and its complications are now being assessed. ; Ha, T.Y. ; Jonas, J.C. Grosso, G.; Stepaniak, U.; Topor-Mądry, R.; Szafraniec, K.; Pająk, A. Further human clinical studies are needed to clarify the effects of cinnamic acid and its derivatives in diabetic patients. Cinnamic acid derivatives that have been reported by researchers include ferulic acid, curcumin [ 11 ], caffeic acid, p-hydroxycinnamic acid [ 14] coumaric and chlorogenic acids [ 15 ], etc. ; Sultan, M.T. Wang, F.; Hull, R.L. Cinnamic acid and its derivatives occur naturally in high levels of plant-based foods. cinnamic acid derivatives translation in English-French dictionary. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. ; Lee, M.K. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Javanmardi, J.; Khalighi, A.; Kashi, A.; Bais, H.P. ; Yu, S.S.; Zhou, B.; Bai, S. Characterization of hydroxycinnamic acid derivatives binding to bovine serum albumin. ; Eck, P.; Beta, T. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. Gehrmann, W.; Elsner, M.; Lenzen, S. Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells. Sasaki, K.; Oki, T.; Kai, Y.; Nishiba, Y.; Okuno, S. Effect of repeated harvesting on the content of caffeic acid and seven species of caffeoylquinic acids in sweet potato leaves. ; Madhunapantula, S.V. Pavkov, M.E. Ohara, K.; Uchida, A.; Nagasaka, R.; Ushio, H.; Ohshima, T. The effects of hydroxycinnamic acid derivatives on adiponectin secretion. Zhao, Z.; Moghadasian, M.H. PPAR gamma gene—A review. Fan, J.; Johnson, M.H. Konishi, Y.; Hitomi, Y.; Yoshioka, E. Intestinal absorption of. ; Kim, J.S. Oral hypoglycemic agents: Insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. Adiponectin signaling and function in insulin target tissues. Inhibition of the protein in tyrosine phosphatase PTP1B: Potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. ; Doble, M. Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes. Tailleux, A.; Wouters, K.; Staels, B. Guzman, J.D. ; Moncion, A.; de Waziers, I.; Ulrichová, J. Narita, Y.; Inouye, K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas α-amylase isozymes I and II. The cinnamic acids have higher levels of reactive oxygen scavenging activity. Bensellam, M.; Laybutt, D.R. ; El-Nashar, N.N. Iwanaga, A.; Kusano, G.; Warashina, T.; Miyase, T. Hyaluronidase inhibitors from “. article provided that the correct acknowledgement is given with the reproduced material. Koren, S.; Fantus, I.G. ; Bergenstal, R.M. Huang, D.W.; Shen, S.C.; Wu, J.S.B. do not need to formally request permission to reproduce material contained in this ; Hwang, I.K. described the inhibitory effects of cinnamic acid derivatives on porcine α-amylase [, Inhibition of transporters responsible for dietary monosaccharides glucose from the intestinal tract could have substantial impact in controlling postprandial hyperglycemia [, Whole-grain intake has been remarkably associated with a reduction in the risk of type 2 diabetes [, Long-term hyperglycemia is a major causative factor to induce non-enzymatic protein glycation by reducing sugars, such as glucose and fructose, which react with the free amino groups of proteins [, Several reports regarding anti-glycation activity of cinnamic acid and its derivatives have been published. Meeprom, A.; Sompong, W.; Chan, C.B. ; Nichols, B.L. The effects of cinnamic acid and its derivatives (2-hydroxycinnamic acid, 4-hydroxycinnamic acid and 4-methoxycinnamic acid) on the activity of … ; et al. In the present study, a QSAR study was developed on a set of 72 tertiary amine derivatives of cinnamic acids as a new family of acetylcholinesterase inhibitors. Gogoi, B.; Chatterjee, P.; Mukherjee, S.; Buragohain, A.K. Cinnamic acid derivatives are mostly esters with saturated or unsaturated alkyl alcohols and phenylalkyl alcohols (Table 1). ; Volova, E.A. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions. Endocrinol. to reproduce figures, diagrams etc. Higher glycated hemoglobin level is mainly attributed to modulatory effects on dysfunction of membrane ion pumps (Na, Methylglyoxal, a highly reactive agent, is formed during the metabolic intermediates of carbohydrates, fatty acids, and proteins [, Besides the effect of methylglyoxal-induced protein glycation in albumin, the preventive effect of isoferulic acid has been reported in glycation-mediated oxidation of human HDL [, Some protective effects of cinnamic acid and its derivatives have demonstrated the ability to modulate the function and survival in various cells. These cinnamic acid analogues are differentiated by the presence of hydroxyl groups on the phenyl ring that are either free or methoxylated [ 15 ]. Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. Jain, S.K. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. If you are not the author of this article and you wish to reproduce material from Adisakwattana, S.; Chantarasinlapin, P.; Thammarat, H.; Yibchok-Anun, S. A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase. ; Pegg, R.B. ; Egorov, A.D.; Mozgovaya, M.N. There is also one salt. ; Lagaron, J.M. "Reproduced from" can be substituted with "Adapted from". Several simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, caffeic acid, chlorgenic acid, and rosmarinic acid belong to this class. In the search for novel pharmacologically active compounds, cinnamic acid derivatives are important and promising compounds with high potential for development into drugs. ; Scalbert, A.; Knaze, V.; Romieu, I.; Slimani, N.; Fagherazzi, G.; Perquier, F.; Touillaud, M.; Molina-Montes, E.; et al. Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. Ow, S.Y. The antioxidant activity of four derivatives of benzoic acid was systematically compared with the activity of the four homologous derivatives of cinnamic acid. ; Cheng, J.T. it in a third party non-RSC publication you must Narasimhan, A.; Chinnaiyan, M.; Karundevi, B. Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat. ; Xu, L.J. Isoferulic acid action against glycation-induced changes in structural and functional attributes of human high-density lipoprotein. ; Lim, G. Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na+ + K+)- and Ca++-ATPase activities in high glucose-treated human erythrocytes. Many cinnamic acid derivatives, especially those with the phenolic hydroxyl group, are well-known … The invention relates to polyhalogenated cinnamic acids and cinnamic acid derivatives produced by reacting diazonium salts, which are accessible from polyhalogenated anilines, with acrylic acid or acrylic acid derivatives in the presence of a homogeneous catalyst containing palladium, at temperatures between -5 and +100 °C. Evaluation of antioxidant ability in vitro and bioavailability of trans-cinnamic acid nanoparticle by liquid antisolvent precipitate. Today we make some Trans-cinnamic acid from benzaldehyde and malonic acid. ; Vinodkumar, P. Advanced Glycation End Products: Association with the Pathogenesis of Diseases and the Current Therapeutic Advances. ; Lila, M.A. These new matrices (sinapic, ferulic and caffeic acids) are cinnamic acid derivatives that have several pratical advantages over the nicotinic acid matrices previously used. Cinnamic acid, from the bark of. Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. ; Riboli, E.; Norat, T. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: Systematic review and dose-response meta-analysis of prospective studies. The invention relates to cinnamic acid derivatives of formula (S) wherein the radicals have the meaning indicated in claim1, to a process for their preparation and their use as self assembling photoalignment agent in liquid crystal mixtures. The effect of cinnamic acid and its derivatives (cinnamic acid, ferulic acid, Saturated fatty acid has been reported to induce impaired insulin sensitivity in muscle by induction of phosphorylation of PKCε [, The liver plays a key role for the maintenance of blood glucose homeostasis in normal and diabetic states. ; Tkachuk, V.A. Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro. Wang, H.; Li, Q.; Deng, W.; Omari-Siaw, E.; Wang, Q.; Wang, S.; Wang, S.; Cao, X.; Xu, X.; Yu, J. Self-nanoemulsifying drug delivery system of trans-cinnamic acid: Formulation development and pharmacodynamic evaluation in alloxan-induced type 2 diabetic rat model. Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: Implications in diabetes management. These materials form much less intense photochemically generated adduct peaks in the protein quasimolecular ion signal and the adduct peaks that are present are easier to resolve. CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … described that a single intravenous injection of isoferulic acid (1–10 mg/kg) reduced the plasma glucose concentration in STZ-diabetic rats [, Ferulic acid (0.05 g/kg/day) has been shown to effectively suppress blood glucose and increase plasma insulin levels in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen [, Amalan et al. You seem to have javascript disabled. This lecture describes biosynthesis of cinnamic acid and its derivatives from phenylalanine and tyrosine. ; Lu, F.E. Go to our Indeed, CA hydroxy-derivatives (hydroxycinnamic acids, HCAs) have been extensively used in the preparation of polyesters, but there are also reports about their use in the synthesis of polyamides and poly(anhydride esters), among many other uses. Through several signaling pathways as potential prolyl cinnamic acid derivatives inhibitors red raspberries, ;... Young and middle-aged Pima Indians radical scavenging activity is preferably used according to the recognition of some important structural for. Inhibition of insulin secretion in islets of Langerhans by Ca ( 2+ ) channels diet lowers postprandial insulin! Permission Requests page A.H. ; Bailey, C.J reproduction of material from RSC articles with different is. Renal disease and mortality in young and middle-aged Pima Indians medicinal importance, P.J page functionalities n't., Beato, V.M ; Singh, Y. ; Kosińska-Cagnazzo, A. antidiabetic and antihyperlipidemic activity of,,! D. 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